Season 4 Intro

Gwen Tennyson's magic aura changes from bright blue to a light cyan

One episode does not take place in the current timeline but rather the alternate future seen in "Ben 10,000"

Ben gains two new alien forms: "Ditto" and "Eye Guy".

The Secret of the Omnitrix movie is set as a three-part episode.

The 3d computer-animated movie Destroy All Aliens takes place one year after.