A small change in the recipe

While refining the rank 2 pills, the only essence of two ingredients were thrown into the cauldron first i.e., the main ingredient and the second most important ingredient. 

After that, the remaining ingredients were refined and the essences from them should be refined in a specific time in order not to fail the pill refinement.

'For Poison resistant pills, I have to mix the essences of the other two ingredients in 2 minutes,'

Ajax took the other two ingredients for the poison resistant pills and started refining them one after another as he thought back to what he had learned in Mason's family alchemy handbook.

That's right.

For every rank 2 pills, there would be a different time to mix the essence of the remaining ingredients to form the pills.

As for the poison resistant pills, it was two minutes.