Red line appeared in their body. From those red lines blood continuously comes out.
Fortunately Sam is present there and continuously healing them. He already expected a situation like this so he was ready.
Even compared to those saints, his aunty and his grandparents are more powerful. They already reached a very high level and this is the reason the situation became that serious.
Even in that situation Natalia and her parents did not give up. They cannot give up in the situation as that will give them a backlash.
Also they did not have a weak will power. Rury and Michael suffer more pain than these. So both of them did not have that much problem. Natalie also has the same situation.
This is also the thing that even makes Sam surprised. But he realised which kind of situation his family went through. It would be abnormal if they were unable to face this kind of pain. .