Chapter 995: The Doctor Does Things in A Very Doctorly Way

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The typical pathological manifestation is the main basis for diagnosing Castleman's disease, and now the diagnostic criteria have become very clear, so the diagnosis has been naturally confirmed.

Castleman's disease, discovered by Doctor Castleman in 1956 and named after him, is also known as giant lymph node hyperplasia, lying between benign and malignant tumors. It's a rare disease characterized by different clinical presentations and histopathological features of reactive lymphoid hyperplasia, with the most prominent feature being large abdominal and thoracic lymph node masses.

The cause is still unknown, but current research suggests that the development of Castleman's disease is related to infection with human herpesvirus 8 and human immunodeficiency virus, immune system dysfunction, and excessive secretion of interleukin 6, among other factors.