Billy suffered a backlash, it was his own retribution.
However, through the narrative from old man Meng, Brian also learned about his own situation.
When he killed Billy, the Blood Moon Radiation Energy within his body had reached the level of activity that old man Meng spoke of, and afterward, it was entirely due to his fierce reliance on fulfilling his obsession and continuously absorbing Spirit Crystals, enhancing his Spiritual Strength, and forcibly maintaining his sanity to complete the process of the Blood Moon fusing with his body.
So, it's fair to say, Brian's true first Transformation occurred at the Mexico border.
The subsequent bodily Transformation
was purely because he was a BUG, his Mutant Ability was completing the deceased's obsessions, reaping the Gift, causing him not only to strengthen his body and absorb the deceased's Spirit Crystal but also to devour the deceased's talent...