In San Francisco, California in a bar it was night time, A young woman Madison , is grabbing drinks with her friends and her co-worker Nate Mulligan approaches and he says to Madison "Hey, Maddie. Listen, I hate to pull you away, but I'm gonna need you to come back to the office with me." Madison says "Really?" Her friends begin smirking, and Nate says " Yeah. Turns out I've gotta file those docs by midnight---." Madison says "Midnight?" Nate says "Yeah, I'm gonna need you to, um..." He sees that she smiles and says " This isn't working at all, is it?" Madison laughing says " No, it's not, Nate." Nate says "Listen, I've had a couple. I shouldn't really drive. Could you just give me a lift—" Madison says " I already called you a cab. [smiling] I'll see you in the morning." Nate smiles briefly, then gives up and walks away; Madison and her friends start cracking up and one of her friends asks "That happen a lot?" Madison says "Only on the days that end with a "y"." Still laughing Madison scans the room and suddenly sees a surly-looking man in a leather jacket, Seated at a table across the bar, he is watching her with a serious look on his face. She stops smiling and she looks uncomfortable, another one of her friends asks " You okay?" Madison says "Yeah." When she looks again, the man is gone and she looks to her friends and says "I've gotta go." Madison is walking quickly to her car, she hears a crashing noise behind her, but when she stops, she sees nothing. She continues walking nervously to her car, Once she reaches her car and drives away, the mysterious man immediately begins following her, watching her leave. The following morning in a office building Madison is filling the coffee pot at the water cooler, she stops, suddenly, when she notices blood on the door to NATE'S office. She goes to the door and pushes it open, a trail of blood on the rug leads to the desk, where Nate is lying, dead. His entire chest has been ripped apart, leaving blood everywhere, Screaming, Madison drops the coffee pot, shattering it to pieces.
In the morgue Sam watches as the employee slides Nate's corpse from his compartment and the employee says " Here he is, Detective." Nate has stitches running along his chest, stomach, shoulders, and throat and Sam says "That's a pretty nasty bite." Employee says "Mm-hmm." Sam says "You know what bit him?" The employee averting her eyes and says "I haven't quite determined that just yet." Sam asks " Come on, Doc. Off the record." The employee says "Okay, way, way off the record ...." Sam says "Sure." The employee says "If I didn't know better, I'd say the guy was attacked by a wolf, But unless I know that the zoo is missing one of their lobos, I'm going with pit bull. eyeing him she says "I like my job." Sam chuckling and says "Yeah, I hear you. One more thing. This guy –- was his heart missing?" The Employee says "Yeah, how did you know that? I haven't even finished my report." Sam says "Lucky Guess."
Back at the motel Dean is sitting on his and Sarah's bed cleaning out his guns and Sarah was doing some research on the other bed and Dean says "This lawyer guy the first heart-free corpse in town?" Sam says "First man, Over the past year, several women have gone missing dead bodies all washed up later in the bay, too deteriorated to draw firm conclusions." Sarah says "But no hearts?" Sam says " No hearts, They were all hookers working Hunter's Point. Now, cops are trying to keep things under wrap, but they're looking for a serial killer." Dean asks "And the lunar cycle?" Sam says "Mm-hmm. Yeah, month after month, all the murders happen in the week leading up to the full moon." Sarah asks "Which is this week, right?" Sam says " Hence the lawyer." Dean says "Awesome." Sarah says "Babes, could you be a bigger geek about this?" Dean says " I'm sorry, babes , but what about "a human by day, a freak animal killing machine by moonlight" don't you understand? I mean, werewolves are badass, We haven't seen one since me and Sam were kids." Sam says "Okay, Sparky. And you know what? After we kill it, we can go to Disneyland." Dean says "You know what the best part about it is? We already know how to bring these suckers down." Holding up a silver bullet and he says " One of these bad boys right to the heart. So, what's our next move?" Sam says "Talk to the girl who found the body."
The three of them arrived at Madison apartment and she lets them inside, Madison says "I don't understand. I already gave my statement." Sam says "Right, well, we just need to verify a few things." Madison says "This is my neighbor, Glen. Glen, this is Detective..." Dean says " Landis, Locke and Dante." He pats both Sarah and Sam's backs, Glen , a bearded man wearing a "Mission Church" T-shirt, stands and says "Well, I guess I'll leave you to it." Madison looks over at him and says "Okay. Thanks for the casserole." Dean says "Oh, how thoughtful." Glen says "Just call if you need anything." They watch he leaves and then Madison says "He's sweet. He came over to check on me. Have – have a seat." They sit down at the kitchen table and Sarah asks "You must be pretty shaken up. You were Nate Mulligan's assistant, right?" Madison says "For two years, yeah." Dean says "So, you knew all about him?" Madison says " Probably knew more about him than he did. Nate was..." She smiles and then says "he was nice." Sam says "But?" Madison says "Nothing, really. I – He had a few scotches in him, and he'd started hitting on anyone in a five-mile radius. You know the type." Sarah notices Dean practically salivating over her, of course she wasn't exactly impressed and then she says "Yeah. I do, actually." Dean's lecherous grin fades as he hears Sarah's tone and he becomes more serious and asks "Did, uh, did he have any enemies?" Madison says "What do you mean? It sure looked like an animal attack." Dean says " No, yeah, we're just covering all the bases. Anyone that might have had a beef with him – a former client, an ex?" Sam notices her think of someone and says "What?" Madison says "Well, this is embarrassing, but my ex-boyfriend, Kurt—" Sarah asks "Kurt have a last name?" Madison says " Mueller. After we broke up, he went kind of nuts. He's... well, he's kind of been stalking me. He got it in his head that something was going on between Nate and I. He showed up at my office." Sam ask "What happened?" Madison says "Kurt got into it with Nate, threw a punch before security grabbed him. I was lucky to keep my job." Dean asks "When was the last time you saw Kurt?" Madison says " A few nights ago. Actually, the night Nate died, We were all grabbing drinks at this bar, and Kurt showed up." Sarah says "And?" Madison says " Nothing. It was ... like he was watching me, Then he was gone To tell you the truth... he scares me."
Outside of the apartment Sarah asks "So, what do you think?" Sam says "Stalker ex-boyfriend? He hates the boss and he was there that night." Dean asks "Think he's our dog-faced boy?" Sam says "Well, it's a theory." Sarah says " We've had worse." Sam says "Yeah." Dean says "What do you say we pay Kurt a visit?" Back inside the apartment, Madison hears something outside, she goes to the window and, gasps, seeing Kurt watching her from the lawn. When she looks again, he is gone. At Kurt's apartment Dean picks the lock, and they enter, While they are looking through the kitchen, the point of view changes to that of an animal, watching them from the corner. Sarah asks "Anything?" Dean closing the fridge says "No, nothing but leftovers and a six-pack." Sam says "Check the freezer. Maybe there's some human hearts behind the Haagen-Dazs or something." As Dean turns to the freezer, they hear a door open and close, followed by a crash outside Dean steps out the sliding glass door onto the balcony. On the wall of the building, he notices claw marks, in the concrete wall, sliding all the way down to the ground and Dean says "Sam, Sarah come here." They both join him and he says "Check it out." Out on the street, A policeman is walking around and hears a crash nearby and he asks "Somebody there?" As he walks down the policeman approaches the dumpster, It growls and jumps to attack the policeman. From the apartment Sam, Sarah and Dean hear a gunshot, They race down to the street, only to find the policeman's body completely mauled.
On the street with the mauled body, Sam says "I'll call 911." Dean and Sarah bends down to the body and Sarah says "I'd say Kurt's looking more and more like our Cujo." Sam says "Dean, if he's out here, we better check on Madison." At madison's apartment The boys and Sarah knock on her front door, Across the hall, Glen opens his door to see the commotion and asks "What's going on?" Sarah says "Police business, Glen." Madison answers the door and asks "What is it?" Sam glancing at Glen and says to Madison "Well, maybe we should talk privately." They go inside and Madison closes her front door and the four of them go into the kitchen, she pours the boys and Sarah coffee and Sam asks "Has Kurt been here?" Madison says "Not exactly." Sarah asks "What exactly does "not exactly" mean?" Madison says "Well, he was outside last night. Just...looking. Just looking at me." The three of them exchange a look and Madison asks"Has he done something?" Sam says "We're not really sure." Dean says "It's probably nothing, but... we just don't wanna take any chances. In fact, one of us should probably stay here with you? Just in case he stops by. Where does he work?" Madison says " He owns a body shop." Sarah asks "You mind grabbing that address for us?" She nods and leaves the room and he says "Thanks." Sam says " All right, you two go, I'll stay." Dean says " Forget that, You go after the creepy ex. I'm gonna hang here with the hot chick." Sarah looks over at Dean and says "Oh really, wow unfreakingbelievable that's the second time you've said something like that." She walks away leaving Dean stunned and feeling a bit bad and Sam says "Yeah dude she does have a point, rock paper scissors it." Sam takes the coffee cups and sets them down, then raises his fist for Rock-Paper-Scissors. Dean plays along, choosing scissors while Sam chooses rock and Sam mocks with concern and says "Dean, always with the scissors." Sam slaps Dean on the shoulder and Dean says " Shut up, shut up. Two out of three." Sam sighs but they lift their hands to play once more Sam's rock beats Dean's scissors and Dean frustrated says "God." Sam says "Bundle up out there, all right?"
Later that morning, Madison is checking through the mail while Sam watches from the kitchen table, He smiles uncomfortably at her and she asks him "Um... do you wanna sit on the couch?" Sam says "No. No, no. I'm okay." Madison says "It's more comfortable." Sam says "Ah, I'm fine." She comes back to the table with a basket of laundry, Dumping it onto the table, she begins sorting through her underwear, pulling up a tiny lacy thong and Sam says " You know, I think I will sit on the couch." She smiles and Sam sits there awkwardly until his phone rings and he answers and Dean says "Let me guess, You're sitting on her couch like a stiff, trying to think of something to say Sam asks "Did you two find Kurt?" Dean says " No, he hasn't been at work all week, But because I'm good, and I mean really, really good, I got a line on where he might be. They both get in the car and dean says "What is she wearing?" Sam says "Bye, Dean" He hangs up the phone and Dean says "Oh, Sammy." Sarah says "I swear Dean it's like you are trying to wind me up anyways let's go to the destination."
Madison comes to sit by Sam on the couch and she turns on the TV to a soap opera. Sam makes a face, visibly annoyed by the choice of programming and Madison says " I saw that." Sam says "Saw what?" Madison smiling says "Okay, this is the deal: my house, my TV. I never get to watch my show, So suck it up." Later, after the credits have rolled, Sam is sitting forward on the couch, completely riveted and he says "Wait, so, so, Kendall married Ethan's father, just to get back at him?" Madison says "Yup. And now she's set to inherit all the casinos that were supposed to go to Ethan." Sam says "What a bitch!" They both laugh and Madison says "Admit it, you're hooked." Sam says "No, no, no, no, no, no. I wouldn't say I'm hooked." She giggle and sam continues and says "You know, can I ask you a question? It's – it's a little personal." Madison says "You've seen my entire underwear collection. Go ahead." Sam smiles and nods and says "Okay, um... well, you're – you're clearly smart. I mean, your house is full, is full of great books, you know? And you're independent ..." Madison says "Uh-huh." Sam asks "What were you doing with Kurt?" Madison says after a short pause " I don't know I mean, it's not like he introduced himself, like, "Hi, I'm possessive and controlling and I like to punch people. Wanna be my girlfriend?" They laugh and then Sam says "Yeah, well, I guess we all make mistakes." Madison says "Yeah, well, mine's wanted by the police." she pauses and then continues and says "You wanna know why I stayed with him? Really? He nods. I was too insecure to leave." Sam says "I find that hard to believe, I mean, you don't really seem like the type" Madison says "Yeah, well, some stuff happened. My life changed, I changed. For the better, I think." Sam asks "What happened?" Madison says " Well, for one thing, I got mugged." Sam was surprised and says "And that's supposed to be a good thing?" Madison laughs and says " I know, it sounds strange and don't get me wrong, it rattled me but – then it hit me. I could keep feeling sorry for myself, or I could take control of my life. I chose the latter first thing I did was tell Kurt he had to go." Sam says "Smart move." Madison says " Apparently everything else just opened up, blossomed It's all been wonderful, really. Sam shrugs and Madison says "What? Doesn't everybody think that being a victim of random violence is the best thing that ever happened to them?" Sam laughing says "Yeah, not so much." Pauses and then continues " You're ... unusual." Madison asks " Unusual, like ..."she circles her finger, pointing to her head, meaning "crazy" "Unusual?" Sam says "No. No. No, no, no. Unusual, like ... impressive." Madison says "You think so?" Sam is about to answer, his phone rings. He smiles apologetically he says "Sorry." He answers and says "Hey." Sarah says "We found him." Sam says "Hey, Good, don't take your eyes off him." Sarah says "Yeah I won't but dean on the other hand might be a pain right."
At Madison apartment she joins Sam in the living room, while he watches the full moon from the window she says "So, um ... I'm gonna turn in." Sam says "Okay, yeah. Well, I'll be here." Madison says "Okay" Sam says "Okay." She smiles uncomfortably and goes into her bedroom Sam sighs, frustrated with himself." Sometime Later Sam watching TV in the living room, He glances at Madison's bedroom there is no movement. Meanwhile Sarah and Dean is standing on the street outside Kurt's, They see a light turn on inside the house and gets their guns ready Suddenly, they both hear glass shattering and they both look s back up to see the lights off in the house. Sarah says "What the ---?" Sarah and Dean runs to the house and bursts through the door, Entering one of the rooms, he sees a woman hovering over Kurt's mauled body She turns towards Dean and Sarah it's Madison and she's a werewolf. Though she still looks human, her eyes have turned an electric blue, her teeth have turned to bloody fangs, and she has long claws. She growls and runs at Dean and Sarah pushing them into the wall, Dean cuts her with a knife which causes her to growls in pain, and runs out the open window.
Sunrise, Sam is still at Madison's apartment , awake, and getting a glass of water he answers his ringing cell phone and says " Dean, you and Sarah okay?" Dean says " Yeah, now that we're conscious, The werewolf knocked us out Sam, it's Madison." Sam says "What?" Dean says "Yeah, awesome job of keeping an eye on her." Sam enters Madison's bedroom to see that she is sound asleep, apparently naked, in bed and he says "Dean, I've been here the whole time. She's in bed, asleep." Dean says "Well, she wasn't an hour ago Check her right arm below her elbow. I nicked her with a silver knife." He hangs up the phone, Madison rolls over and wakes up, noticing Sam and says "Morning." She sits up and notices that she is naked, covered only by her bed sheets. Sam sees the wound on her arm and she says "Um... where are my pajamas?" Sam upset, leaves the bedroom Madison asks "Sam? What's going on? Where are you going?" She jumps out of bed, wrapping the comforter around her, and follows him to the living room, where he is locking the front door and Sam says "I'm not going anywhere. And neither are you."
Later Madison is seated in a chair, with her wrists bound. Sam is standing in front of her, holding a gun and she says "You're psychotic. The whole "I'm a cop" trip – God, I am so stupid." Sam says "Well, I guess neither of us are who we said we were, huh?" Madison says "Sam, you're sick, okay? You're imagining things. Monsters don't exist, not really." Sam says "You know what? Save the act." She starts crying and says to Sam " It's not an act! I am not a werewolf! There's no such thing! It's made up, all right? Th– They're not real! You know they're not real!" Sam says "No?" He points to the wound and asks her "Then where did that come from?" She then says " I don't know! Sam, God, you need help. Please, don't do something that you're gonna regret. I'm not what you think I am. I'm not." Sam visibly upset, hears knocking at the door. He opens it to see Dean and Sarah , who enters and smirks at Madison and he says "How you doin'? Our heads feel great btw." Sam says "We've gotta talk." He brings Sarah and Dean into another room and says "She says she has no idea what I'm talking about." Dean says "She's lying." Sam says "Or maybe she really doesn't know she's changing, you know? Maybe – maybe when the creature takes over, she blacks out." Dean says "Like a really hot Incredible Hulk. Come on, dude, she ganked her boss and her ex-boyfriend,that doesn't sound rash and unconscious."
Sam says "Yeah, but what if it was, Dean? I mean, what if some animal part of her brain saw both those guys as threats? Hell, the cop, too." Dean asks "What are you, the Dog Whisperer now?" Sarah doesn't say anything she does feel bad for Madison but then she understands from Dean's point of view as well as Sam's, Sam says " Look, man, I just... I don't know, there, there, there was something in her eyes." Dean says "Yeah, she's killing people!" Sam says "But if she has no control over it—" Dean says "Exactly, She can't control it even if she's telling the truth, it's not gonna change anything." Sam says "I'm not putting a bullet through some girl's chest who has no idea what's happening." Dean says " Sam, she's a monster, and you're feeling sorry for her?" Sam says " Maybe I understand her." He pauses and then continues "Look, there might be another way we can get the job done without having to waste her." Dean says "Are you thinking what I think you're thinking?" Sam flipping through their dad's journal says "Dad's theory – "lycanthropy might have a cure if you kill the werewolf who bit you, severing the bloodline"." Sarah says "MIGHT have a cure. Meaning "who the hell knows?"" Sam says "It's worth a shot." Dean says "We don't even know where to start looking, all right? I mean, the puppy that bit her could be anyone, anywhere. It could've been years ago."
Sam realising something says "No. I don't think so." He leads Dean and Sarah back to the living room, where Madison is still seated and he asks "Madison, when were you mugged?" She doesn't want to answer, just looking at him and he says " Please. It's important, all right? Just answer the question." Madison says "About a month ago." Sam asks "Did you see the guy?" Madison says "No. He grabbed me from behind." Sam asks "Did he bite you?" Madison says after a pause "How did you know that?" Sam asks "Where?" Madison says "On, on the back of my neck." Sam hows her that he is setting his gun down, and goes behind her, gently brushing her hair away and exposing a scarred lump the size of a golf ball on her neck and Sarah says "Oh, that's just a love bite. Believe me, that could have been a lot worse. Where were you at the time?" Madison says "Walking home from a friend's loft." Sam asks " Let me guess. Not too far from Hunter's Point?" She nods. Sam, Sarah and Dean are back in the other room; Sam closes the door and faces Sarah and Dean and says "The same place where those other murders happened. I'm telling you, it's a werewolf's hunting grounds." Dean says "Maybe, but that doesn't mean it's gonna be out there tonight." Sam says "It's the right time of the lunar cycle. Look, I know it's a long shot." Sarah says "Hey, you're forgetting something. Maddie's probably gonna turn soon, all right? We can't just let her take off to an all-you-can-eat buffet." Sam says "I'll stay with her." Dean says "And if she busts loose?" No response "Sam?" Sam says "I'll do it." Dean says "Sam." Sam says " I'll shoot her, all right? But Dean and Sarah I need you two to go out there At least go look for the thing. Dean, Sarah please we can save this girl. Dean after a pause, realizing that Sam is feeling more intensely than usual says "Fine." And so does Sarah, Sam nods Sarah and Dean leave the apartment, Sam rejoins Madison , who is still crying and she says "Please. Just let me go." Sam looks at her sympathetically and pulls up a chair to sit in front of her and says "Look ... I know you're scared. I also know that there's no way in hell you're gonna believe me. But I'm doing this because I'm trying to help you. I'm not gonna lie, all right, the odds aren't exactly in our favor. But if this goes the way I pray it does ... I'll untie you, and I'll walk out that door, and I'll never come back. You'll live the rest of your life. And I'll just be a bad memory." Sam is emotional, tearful as is Madison.
On Hunter's point night time, A woman, clearly a hooker, is walking the dark street alone. She stops when she hears an animal howling, and looks nervous. Back at Madison's apartment Sam is watching the full moon while Madison sits in the chair. Suddenly, her fingernails grow, stretching into claws, Her eyes turn bright blue and she bares her fangs. Sam turns just as she breaks loose from the chair, She knocks him to the ground, but he quickly gets up, aiming his gun back at Hunter's point The hooker is running down the street when suddenly, she comes face-to-face with the animal, it starts chasing her down the street, At Madison's apartment Sam keeps his gun aimed at Madison, Just as she lunges at him, he moves out of the way, forcing her into her bedroom. He moves the entertainment center in front of the door, trapping her inside. Back at Hunter's point, The werewolf catches up with the hooker, dragging her screaming across the pavement and Dean says "Hey!" The werewolf looks up just as Dean shoots him, three times in the chest. The werewolf is Madison's neighbour Glen, The woman stands up, frightened, and glances at Dean and Sarah before running away and Sarah says "You're welcome." They crouches down next to GLEN, who is coughing and choking, His mouth is covered in blood. After a moment, his fangs retract, and he returns to normal and he says " It happened ... again. Where am I? H–help me. Oh, God. Oh my God." He coughs sarah says " All right, easy, Glen. Just take it easy." They watches as GLEN dies, his eyes glazing over.
It was the morning back at Madison's apartment, She wakes up dressed as Sam opens the bedroom door and he says "It should be over now. You'll never see me again."Standing Madison surveys the bedroom Furniture is overturned, and there are claw marks covering every inch of the walls, When she turns around, Sam is gone. Outside in the Impala, The three of them are parked outside of Madison's apartment Sarah says "It was sort of sad, actually Glen had no clue what was going on. Hey, why do you think he turned Madison instead of just killing her in the first place?" Sam says " I don't know. I mean, he kind of seemed to have a thing for her." Dean says "Maybe his primal instinct did, too. Maybe he was looking for a little, uh, hot breeding action." Sam says " Yeah. Something like that." Dean says "So?" Sam says "So, What?" Dean says "Speaking of Madison." Sam says "Oh, whatever." Dean says "Don't "whatever" me, man, you liked her. Maybe, uh—" Sam says " Dean, she thought I was a stark-raving lunatic." Sarah says "You saved her life." Sam says " Yeah, but she doesn't know that." Madison appears at the window and says "You know, for a stake-out, your car's a bit conspicuous. What are you still doing here?" Dean says to Madison "Honestly? Uh, we're pretty sure you're not gonna turn tonight, but we've gotta be a hundred percent, so... you know, we're ... lurking." Sam says "I know this sounds crazy." Madison says "Sure does. Well, if we're gonna wait it out... we might as well do it together."
Inside Madison's apartment she lets Sarah and the boys inside and closes the door behind them and Madison says "You were telling the truth, weren't you? About everything. What you did – it was to help me." Sam says "Yeah." Madison asks "I did all of those horrible things ... when I turned." Sam says "You didn't know." Madison after a pause says "So, when will we know for sure? Moonrise?" Sam says "No, I don't think so. You turned middle of the night last night. I think we've gotta hang in until sun-up." Sarah and Dean has been watching Sam carefully, he gives a tiny nod and then says "Well, it looks like we've got ourselves a few hours to kill. Poker, anyone?" Later, the four of them of them watch as the sun sinks and the moon rises. Dean lays his gun on the table. Sarah, Sam and Madison watch from the couch and Sarah joins Dean and he says "Oh, no, you guys talk." A few hours later, they watch from the window as the sun comes up and Madison asks "Does – does this mean it worked?" Sam relieved says "Yeah. I think so." Madison sighing with relief says "Oh, God, thank you. Thank you so much." She gives Sam a hug, Dean clears his throat, and they pull away and she laughs and says "You, too, Dean and Sarah, Thank you." Sarah smiles and says "It's no problem, just happy it ended well to be honest." Dean says "Aw, don't mention it." There was an awkward pause and then Dean says "So, me and Sarah just gonna head back to the hotel and ...watch a movie or something." They leave the apartment Dean, pumping his fist in the air as they leave.
Madison says "That was smooth, heh." Sam says "He means well, but..." Madison says "You mean, he thinks you're gonna get laid." Sam says " Look, I—" Madison says "It's okay." Sam says "No. I know I scared the crap out of you, all right? I–I mean, I tied you to a chair." Madison says "That's right up there with me scratching up your face." Sam says "There's just no way ... we could go back, you know? Before it happened." Madison says "You're right. There's just no way." Sam shakes his head, Then, after a moment, Madison gives in and kisses him. Sam immediately responds, pushing her against the wall, They strip each other of their clothing and make their way to the bedroom, falling back onto the bed. Throughout the night, they continue to make passionate love, letting go of all they had been holding back. Hours later, they fall asleep in each other's arms, completely content. The full moon appears and Sam wakes up and looks around, He hears a growl and turns to see Madison, who has returned to her werewolf form, eyes blue and fangs bared. Before Sam can catch her, she jumps out the window, leaving him stunned.
Sam arrives at the Motel where Sarah and Dean are staying, he pounds on the door, Dean opens it and Sarah gets out of the bathroom fully dressed and sam comes inside and Dean closes the door behind him and Sam breathless says "She – she turned." Sarah says "What?" Sam says "I couldn't grab her in time." Dean says "We'll find her, Sammy." The three of them exit the motel building, Sam, Dean and Sarah are quickly coming down the steps of the CHINA SEA MOTEL and Sam says " I already called Bobby. He doesn't know anything. Except he knew severing the bloodline wouldn't work. That's everyone. They all say it's impossible to reverse it." Dean says "How come she didn't turn when we were with her?" Sam says "Dean—" Dean says "So, what, you put her to bed and then she wolfed out? Maybe she's gotta be asleep to turn." Sam says "What the hell does it matter, Dean? Look, we've gotta find some way to help her, some legend we missed or something." Dean says "If there was, don't you think someone we know would've known it?" Sam says "Well, then we have to look harder! Until we find something." Dean says "Sammy, I don't think we've got a choice here anymore." Sam says "What?" Sarah says " I hate to say it. She's a sweet girl, but part of her is—" Sam says "Evil." Dean says "Yeah." Sam says "Yeah, that's what they say about me, Dean! So me you won't kill, but her you're just gonna blow away?" His phone rings and he answers it and from a phone booth it's madison and she says "Sam?" Sam says "Madison, where are you?" Madison says "I don't – I don't – I don't know where I am." Sam asks "Well, do you see any street signs?" Madison says " Um ... yeah, yeah, Middle Point." Sam says "All right, hold on, Maddie. We're coming to get you, just stay where you are."
Back at Madison's apartment the four of them are in the living room, The gun is sitting on the table and Madison says "I don't remember anything. I probably killed someone last night. Didn't I?" Sarah says " There's no way to know yet." Madison says "Is there something else we can try to make it go away?" Sam says "We'll find something. I mean, there's gotta be some answer, somewhere." Dean says " That's not entirely true. Madison, you deserve to know. We've scoured every source. There's just no cure." Madison looks to Sam and asks " Is – is he right?" Choking up Sam stands and turns away and Dean says "Well, we could lock you up at night, but ... you bust out, and some night you will, someone else dies." He pauses and says "I'm sorry. I am." Madison crying and exhales and says "So, I guess that's all there is to it, then." Sam says "Stop it. Don't talk like that." Madison says "Sam, I don't wanna hurt anyone else. I don't wanna hurt you." She picks up the gun and brings it to him, Sam says "Put it down." Madison says " I can't do it myself. I need you to help me." Sam says "Madison, no...." Madison says "Sam... I'm a monster." Sam says "You don't have to be. We could find a way, all right? I can. I'm gonna save you." Madison crying harder says "You tried. I know you tried. But this is all there is left. Help me, Sam. I want you to do it. I want it to be you."
Sam says "I can't." Madison says " don't wanna die. I don't. But I can't live like this. This is the way you can save me. Please. I'm asking you to save me." Sam shakes his head, Dean walks over to them, Sarah doesn't move and he carefully takes the gun from Madison and Sam walks to another room, Sam is choking back tears, Dean and Sarah enter quietly and Dean says "Sam." Holding up the gun and he says "I'm sorry." Sarah touched Sam's arm which was appreciated and Sam putting his arm around Sarah's shoulder and they side hugged and Sam says with tears in his eyes, "No, you two are right, she's right as well." Dean says "Sammy, I got this one. I'll do it." Sam says "She asked me to." Dean says " You don't have to." Sarah says "He's right you know you don't have to do it." She goes over to Dean and Sam says tears sliding out his eyes "Yes, I do. Please" He holds his hand out for the gun, tears streaming down his face. Dean hands it to him and Sam says "Just wait here." He glances back at Dean and Sarah, Dean's hugging her as Sarah starts crying her eyes out and then after a minute they both heard a single gunshot.