In the wake of several near-cataclysmic events, humanity created the Cure, a DNA-altering antidote to death by disease and old age. But all cures come with side effects: a small percentage of the population develops a wide range of powers, some lethal to others and some lethal to the wielder.<br><br>These people are called the Estranged, hunted and shunned, safe only on the Island of Exile. It is here that Kaeva and Eddie meet ... and where they set a prophecy in motion, quite possibly sealing their own demise, and even the end of Exile.